ABSTRACT
Neurophysiological, pharmacological, and clinical psychological studies have convincingly demonstrated the relationship between the gross memory disorders described by S. S. Korsakov and lesions of the medial Papez structures of the brain. The syndrome of focal lesions of the medial brain structures consisted of mnemonic disorders, frequently accompanied by disorders in the regulation of emotional and autonomic responses. The extent of memory disorders does not depend on the size and site of the diencephalic tumor, but is associated with the stage of development of the pathological process and the functional state of the involved brain areas. The depression of a normal flow of afferent impulses into the cerebral cortex from nonspecific structures of the brain stem increased in proportion to the extent of memory disorders, and in the last group of patients was combined with pathological influences from the brain stem.
