ABSTRACT
This chapter examines the impact of physical activity upon the normal functioning of the kidneys, and explores such manifestations of temporary dysfunction as exercise-induced microproteinuria and microhaematuria. It considers the potential of developing acute renal failure during a prolonged bout of exhausting exercise and the possibility of chronic renal damage in athletes with an excessive intake of creatine supplements or non-steroidal anti-inflammatory drugs (NSAIDs). The chapter examines the place of exercise programmes in the rehabilitation of patients who are undergoing dialysis or who have received renal transplants, and it considers the possibility that regular physical activity may reduce the risk of renal cancer. A large intake of anti-inflammatory drugs can also have adverse effects on the kidney, particularly in individuals whose bodies normally rely on an increased prostaglandin secretion to counter a reduced renal blood flow. In humans, vigorous physical activity leads to a progressive drop in the glomerular filtration rate (GFR) as renal perfusion decreases.
