ABSTRACT
Inflammation from innate immune responses dominates the illnesses created by biotoxins. Innate immunity can heal, but can also become the overwhelming source of illness caused by exuberant host responses. Inflammation from innate immune mediators does not quickly come to mind thinking about "wear and tear" arthritis or overuse syndromes like rotator cuff injuries or tennis elbow. Curiously, the same inflammatory mediators involved in response to adverse environmental exposures also play major roles in musculoskeletal pain. The fundamental elements of chronic inflammatory response syndromes (CIRS) also have importance for musculoskeletal pain and musculoskeletal injury, both as a whole and as individual effectors. The application of genomics to complex human illness is in its early stages. Already, tremendous advances in medicine and science have resulted from transcriptomics.
