Premature rupture of membranes at or near term

Placental alpha-microglobulin-1 is a 34-kDa glycoprotein abundant in amniotic ˜uid (2,000-25,000 ng/mL); there is a negligible amount of this glycoprotein in vaginal ˜uid with intact fetal membranes (0.05-2.0 ng/mL) [2,4,5]. AmniSure is a bedside immunoassay that uses the delta in concentration of placental alpha-microglobulin-1 for diagnostic accuracy. AmniSure has a sensitivity of 98.7% to 98.9% and a specicity of 87.5% to 100% [4,5].