ABSTRACT
Cancer is becoming one of the most devastating malignant diseases threatening human health and the most terrible cause of death worldwide. For cancer, either conventional chemotherapy therapies or gene therapies are associated with poor therapy effect such as low specificity and non-selective biodistribution, not mention to the combination of both. The polymeric nanobiomaterial with the unique biological properties targeted delivery antineoplastic drugs or genes can overcome these problems. Co-delivery antineoplastic drugs and genes have been widely explored for enhancement of their therapeutic efficacy in treating cancers. Besides, stimuli-responsive polymeric nanobiomaterial can enhance the bioavailability of drugs and genes at the disease site thus further improve the effect of treatment. In this paper, we reviewed the current status of polymeric nanobiomaterial to delivery different antineoplastic drugs or genes for cancer via passive targeting strategies and active targeting strategies. These current advances show a bright future to the development of cancer therapy against combination of chemotherapy therapies and gene therapies.
