ABSTRACT
One of the most critical problems in the treatment of many diseases is due to the disproportionate delivery of drugs and therapeutic agents to the target sites. Polymer micelles have emerged as a very important system for targeted drug delivery. The aim of drug delivery system is to deliver drugs to the right place, at the right concentration, for the right period of time. As drug characteristics differ substantially in chemical composition, molecular size, hydrophilicity, and protein binding, the essential characteristics that identify efficacy are highly complex. The first liposome drug delivery system to gain Food and Drug Administration approval in 1995 was Doxil for the treatment of AIDS associated Kaposi's Sarcoma. Targeted delivery for cancer therapy can be achieved through, enhanced permeability and retention, tumor-specific targeting, targeting through angiogenesis, targeting tumor vasculature, and delivery of specific agents like gold and silver nanoparticles.
