ABSTRACT
The influence of the structure of isobornylphenols on their kinetic characteristics in the initiated oxidation of methyl oleate or ethylbenzene and autooxidation of methyl oleate in thin layer in mixtures with lecithin is studied, for example, 2-isobornyloxyphenol (I) and 2-isobornylphenol (II). The destruction of the intramolecular H-bond in I molecule while carrying out reactions in polar medium results in its increased ability to interact with peroxy radicals and the stable free radical diphenylpicryl- hidrazyl (DPPH). Effect of lecithin on the inhibitory efficiency of investigated isobornylphenols is found to depend on the initiation rate in the oxidation process and the ability of substances to form complexes with lecithin. In presence of isobornylphenols aggregates of lecithin both the size distribution of particles and the diameter of the main fraction depending on a polarity of medium change. Thus, isobornylphenols act upon the different parameters of the oxidation processes in the complex model systems. It allows us to suppose that the biological activity of isobornylphenols is due to their ability, both to influence on the different stages of the physicochemical regulatory system of the lipid peroxidation in tissues and to affect the structural state of the cell membranes. The data obtained help in checking the properties of various compounds on different model systems to carry out the preliminary choice of the most promising biologically active substances for practice use the medium polarity.
