ABSTRACT
The Immunoglobulin E (IgE) plays an important role in Atopic Dermatitis (AD) pathogenesis, in principle, it could serve as a marker for AD. Though, in some studies, showed no evidence of their correlation. The severity of AD is commonly evaluated using the Scoring Atopic Dermatitis (SCORAD).This study aim was to assess the correlation between serum IgE levels and severity of AD. Serum from 20 AD outpatients was collected and their IgE levels were evaluated using Enzyme-Linked Immunosorbent Assay (ELISA) technique. The SCORAD assessments were also performed. There were significant differences serum IgE levels between AD and control group (p < 0.05). Furthermore, the correlation analysis result between serum IgE level and SCORAD was significant (r = 0.73; p < 0.05). The result showed that the increased of IgE level indicated the increasing of SCORAD.We suggest serum IgE level proved to be a useful tool in assessing the severity of AD.
Keywords: atopic dermatitis, immunoglobulin E, SCORAD
