ABSTRACT
Trigona propolis is known to contain a wide range of substances that are beneficial to humans. However, there are no data on the effect of Trigona propolis on hemorrhagic gastritis. This study aims to understand the mucoprotective effect of Trigona propolis against hemorrhagic lesions in the rat’s stomach. The study used 21 male rats that were divided into three experimental groups. Group 1 was given propylene glycol, group 2 was given Trigona propolis (300 mg/kg BW), and group 3 was given ranitidine (50 mg/kg BW). All rats were also given ethanol 99.5% (1 mL) one hour later. On the 3rd day, the rats were dissected, the stomach was incised, and the characteristics of hemorrhagic lesions were recorded. The average lengths of hemorrhagic lesions in the three groups were 81.86 ± 15.52 mm, 43.29 ± 9.23 mm, and 60.14 ± 12.88 mm, respectively, and the differences were significant between the groups (p < 0.05; one-way ANOVA). This study showed that Trigona propolis has a mucoprotective effect and therefore can be used as a preventive treatment for hemorrhagic gastritis induced by ethanol 99.5%.
