ABSTRACT
This chapter provides an introduction to estimation of the cumulative incidence of infection of infectious diseases using serologic data. We start with a simple illustration of seroprevalence data collected at different time periods of an epidemic, and use this scenario to illustrate inference from different study designs. We contrast two serologic study designs, namely cross-sectional studies and longitudinal studies, and their use to estimate the cumulative incidence of infection and the corresponding confidence intervals. The study designs are accompanied by applied examples.
