ABSTRACT
Among thousands of drugs in the world, more than half have chiral characteristics, ~20" are single enantiomers, and the rest of the drugs are racemic in nature. Since the 1980s, capillary electrophoresis (CE) has been used in the pharmaceutical industry for the separation of large and small biological molecules as drugs. Chiral CE is a treasured instrument for the separation of chiral drugs, as most of the pharmaceutical products are chiral and each enantiomer exhibits different toxicity and pharmacological behavior. Ofloxacin enantiomer analysis is very important in pharmaceuticals, especially in the department of quality control to investigate the pharmacokinetics, designing of in vitro studies and development of novel chiral products. Ofloxacin enantiomers were separated and quantified using capillary zone electrophoresis in extremely diluted samples. Chiral CE is a treasured instrument for the separation of chiral drugs, as most of the pharmaceutical products are chiral and each enantiomer exhibits different toxicity and pharmacological behavior.
