ABSTRACT
Capillary zone electrophoresis (CZE), in the last 25 years, has emerged as a robust analytical technique that has gained wide acceptance in the biomedical environment. Parkinson's disease (PD) is the second most frequent neurodegenerative illness only surpassed by Alzheimer's disease. The thalamus is a deep-brain nucleus and is the main relay station of sensory information to the cerebral cortex. Cerebral micro-dialysis has become one of the most reliable and widely used techniques for the in vivo monitoring of neurotransmitters in the central nervous system (CNS). Surgery is necessary in a limited number of PD patients who do not respond well to pharmacological treatment and have a severe disability score, making it impossible for the patient to complete simple daily chores. New possible strategies in pharmacological treatments of PD patients in the present are based on modifying the dopamine neurotransmission and open up the possibility of looking at gamma-aminobutyric acid (GABA) antagonists that could have a preferential effect in the thalamus.
