ABSTRACT
Cancer treatments have revolutionized during the past decades with many new anticancer therapies being developed and approved for a broad variety of cancer types. The incidences of adverse events to anticancer therapies have increased in parallel to the rapid emergence of novel treatment modalities, new regimens of combination therapies, and prolonged survival. Dermatologic adverse events can strongly impact patients’ quality of life by affecting the appearance, emotions, and activities of daily living. Dermatologic adverse events can lead to dose reduction or discontinuation of anticancer therapies, which may compromise clinical outcomes and even result in life-threatening conditions. Patient counseling, preventive strategies, early recognition and diagnosis, and prompt management of dermatologic adverse events are essential for keeping patients on the anticancer treatments, optimizing tumor responses, and maintaining quality of life. This chapter aims to give an overview of anticancer therapies including cytotoxic chemotherapies and targeted therapies, radiation therapy, stem cell transplantation, immunotherapies, and CAR-T cell therapy and their associated dermatologic adverse events. Detailed descriptions of clinical presentation and management of each dermatologic condition will be discussed separately in the following chapters.
