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Factors Affecting Distribution of Toxicants to Tissues

The distribution of toxicants to tissues is dependent on several factors: (1) physical and chemical properties of the toxicant, (2) concentration of the toxicant in the blood and in the tissues (i.e., concentration gradient), (3) volume of blood flowing through a specific tissue, (4) tissue specificity or preference of the toxicant, and (5) presence of special “barriers” to slow down toxicant entrance.