ABSTRACT
After the advent of rDNA technology in 1970s, discussions began within the scientific community about the risks associated with recombinant DNA/genetic engineering experiments. In 1975, at Asilomer, California, an International meeting was held which formulated the first set of recommendations on safety of recombinant DNA experiments. These formed the basis of subsequent biosafety guidelines and regulations in USA and other countries. Biosafety concerns were primarily focused towards the safety procedures for recombinant DNA work within the laboratory. Whereas risk assessment and management procedures are intended to identify and minimize potential negative effects on human health and the environment, risk communication is an integral part of biosafety procedures to ensure public acceptance of genetically modified organisms (GMOs). If GMO is to be produced then identification of DNA sequences encoding the desired trait, choice of marker gene, regulatory sequences for the expression of transgene, transformation method, etc. should be considered.
