ABSTRACT
Traumatic brain injury (TBI) is a term that refers to an event in history, rather than to a syndrome or disorder. Once the diagnosis is established, TBIs have traditionally been categorized into mild, moderate, and severe grades based upon the severity of the injury. Given the breadth of location, severity, and mechanism of TBIs, a range of symptoms is common beyond acute loss of consciousness and amnesia. Neuroimaging studies have provided insights into the neural mechanisms underlying Working Memory (WM) deficits in TBI patients. In particular, functional magnetic resonance imaging studies have been useful in attempting to link abnormal brain function to particular WM impairments in this population. The more chronic neurological sequelae of mild TBI have traditionally been captured by the diagnosis of post-concussive syndrome. Randomized controlled clinical trials have evaluated the efficacy of a moderate number of medications for treating chronic cognitive impairment in TBI patients.
