ABSTRACT
The domain of nanomedicine has brought forth several promising drug delivery technologies using diverse nano-scale carriers through diverse routes of administration. Development of products poses major challenges to pharmaceutical development scientist, as more than one-half of new molecular entities exhibit poor and inconsistent bioavailability. Lipids are considered as one of the safe and ultimately biocompatible materials for drug delivery. Important factors like nature of the lipid, physiological and molecular properties of the drug dynamically affect the particulate nature of the lipidic systems along with permeability and drug absorption potential. Formation of stable lipidic systems can be achieved by judicious selection of ratio of lipids-surfactants and optimizing the process parameters involving in homogenization technique. Vesicular systems are a novel means of drug delivery that can enhance bioavailability of encapsulated drug and provide therapeutic activity in a controlled manner for a prolonged period of time.
