Dendrimers as Nanomedicine in Cancer Therapy
In recent years, dendrimers have attracted scientists particularlyin various facets of cancer therapy. The application of dendrimers in cancer therapy ranges from improved pharmacokinetic profile of poorly permeable anticancer drug, increased aqueous solubility of hydrophobic drugs to targeted drug delivery, gene therapy, cancer imaging, photodynamic therapy (PDT), boron neutron capture therapy (BNCT), etc. Dendrimers have shown passive targeting via the enhanced permeation retention (EPR) effect and pH-sensitive drug release as well as active targetingusing various ligands such as mannose, folic acid, transferrin, antibodies, and peptides, etc. In this review, we have summarized latest advances in dendrimer-mediated cancer therapy forspeculated clinical applications of dendrimers.