ABSTRACT
Figure 9.1 DCs arise from the bone marrow (BM) and then migrate to peripheral tissues and lymphoid organs.
macrophage colony-stimulating factor receptor (M-CSFR) and fms-related tyrosine kinase 3 (Flt3), which ultimately leads to plasmacytoid DC (pDC) and conventional DC (cDC) subtypes [8, 9]. Subsequent to lineage commitment, DCs respond to a wide range of stimuli such as Flt3 ligand (Flt3L) and GM-CSF (Csf-2) to perform different functions [10-13].
