ABSTRACT
The amino acid sequence of actin is highly conserved in most eukaryotic organisms, and each cell typically expresses only one or two homologous actin isoforms. Yet, actin filaments play important roles in a number of diverse activities in each cell. Each of those actin functions depends on interactions with a specific set of actin binding proteins. In a number of cases, local biochemical signaling to regulate the activities of actin binding proteins has been shown to contribute to the spatial and temporal regulation of those interactions, but not all aspects of the local regulations of the interactions can be explained by local biochemical signaling.
