ABSTRACT
Nanoscale fibrous architecture based upon the natural extracellular matrix (ECM) has provided inspirational potential in the field of scaffold-based tissue engineering. A range of synthetic and natural biomaterials has been developed via an electrospinning process in order to mimic the nanofibrillar ECM structure. This process can be technically diversified, depending on the engineering strategies needed for various tissues. Guided by nanotopographical cues incorporating chemical factors from biomaterials, the cells cultured on electrospun fibrous scaffolds can show distinctly different behaviors. Based on the numerous biological phenomena involving nanofiber scaffolds, the recent research achievements spawned by 512the electrospinning techniques will shed light on tissue regeneration and artificial organs for use in bionanotechnology.
