ABSTRACT
Therefore, it has been suggested that inhaled nanoparticles were cleared by the alveolar macrophages and/or transferred to the pulmonary interstitium [13]. In a recent study, Shinohara et al. determined the deposition, clearance, and translocation of C60 nanoparticles (18-29 nm, 100, 200, and 1000 micrograms per body) exposed male Wistar rats for 18 h, 3 days, 1 week, 1 month, 3 months, and 6 months by intratracheal instillation and inhalation. They found that the concentration of C60 in the brain was below the detection limit. C60 clearance was fast clearance after deposition on lung surface and slow clearance after retention in the epithelium. The calculated biological half clearance time of C60 was 15-28 days [14].
