ABSTRACT
224Betulinic acid (BA) is one of the triterpene acid compounds showing a remarkable cytotoxicity on various tumor cells. Betulinic acid as the main constituents of Melaluca cajiput sp. bark is one of the promising compounds that has anti-retroviral, anti-malaria, anti-HIV, and anti-inflammatory activities. The therapeutic properties of peptides derived from betulinic acid aroused our interest in synthesizing the betulinic acid peptides. We herein report the synthesis of several natural amino acid–BA peptides using standard coupling protocols (HOBt, HBTU). In addition, enantiopure cyclohexene silyl ether–BA peptide was successfully synthesized.
