Synthesis Of Enantiopure Azido Trimethylsiloxy Cyclohexene Derivatives: A Useful Intermediates For The Synthesis Of Tamiflu

234Peptides bearing natural amino acids scaffolds are widespread in nature and known to exhibit a wide array of biological activities. As part of research endeavor in investigating the potential of enantiopure azido cyclohexene silyl ether, we hereby present an approach toward the intermediate synthesis of antiinfluenza drug, Tamiflu, starting from azido cyclohexene silyl ether. The methodology involved reduction amination of azide, followed by Boc protection of amine termini. Deprotection of Boc group and coupling reaction with natural amino acids using standard peptide coupling procedure afforded enentiopure cyclohexene peptides.