ABSTRACT
In 1982, dendrimers were proposed for the first time for their potential application as 'molecular containers'. The dendrimer-drug properties of various dendrimeric polyplexes have been extensively investigated and have attained a key position in the domain of supramolecular chemistry. Dendrimers are superior when compared with the other currently available drug delivery systems such as liposomal and linear polymer formulations. This is because of their defined architectural control, high drug loading, and precise as well as controlled drug loading/drug release. Dendrimers also possess the capability of simultaneously loading hydrophobic and hydrophilic drugs. This chapter suggests that despite significant advances, effective treatment of ophthalmic diseases remains a challenge, because of the unique anatomy and physiology of the eye including the presence of ocular barriers. It highlights the selected ones in the past few years. Designing suitable dendrimers and toxicity issues are some of the major hurdles which prevent dendrimer-based drug delivery systems from being translated from basic research to clinically useful products.
