ABSTRACT
Biosensors are specific analytical tools which can be used for determining the concentrations of various biomolecules, including ions, in biological fluids. They are often designed using electrodes/optical transducers that are coupled with catalytic and/or molecular recognition elements which may be enzymes and/or antibodies. There are numerous other areas of biological chemistry in which the applications of dendrimer-based systems may be of help although the evidence, for some of them, is either scanty at the moment or a wide bridge still exists between basic research and its clinical translation. Polyamidoamine (PAMAM) dendrimers are expected to possess potential applications to enhance the solubility for various drug delivery systems. Dendrimers are known to have hydrophilic exteriors as well as interiors, and this is responsible for its unimolecular, micelle-like nature. Dendrimer-based carriers provide an opportunity to enhance the oral bioavailability of many problematic drugs. Of late, dendrimer Layer-by-layer (LbL) films have also been employed as gating materials for preparing field effect transistor (FET) biosensors.
