ABSTRACT

The potential of three-dimensional scaffolds made of Polyhydroxyalkanoates (PHA) was evaluated in rabbit articular cartilage defect model. C. R. Rambo et al. demonstrated osteogenic potential of the composite material based on P in polylactide matrix, showing that incorporation of copolymer microspheres into the matrix enhanced the physical/mechanical properties and porosity of the material and, thus, resulted in better mesenchymal stem cells proliferation compared with polylactide matrix. Cranial flat bones have a low self-healing ability because of their biological properties, determined by the embryonal development and histophysiological parameters. The fractures of the skull bone tissue are usually ductile fractures: buttonhole fractures with smooth edges. The monocyte counts were also increased, because of migration of the reserve cells from bone marrow and the marginal blood pool, frequently associated with the musculoskeletal traumas. The edges of the defect consisted of the new bone tissue with osteoblasts synthesizing intercellular substance, osteocytes, and a few Haversian canals.