ABSTRACT
This chapter focuses on MIL-101(Cr) which is one of the most well-investigated metal-organic frameworks (MOFs), and describes its adsorption in the nonaqueous phase. Adsorption of polar ethylcinnamate versus nonpolar styrene was studied on activated MIL-101(Cr). Molecules of many biologically active compounds such as DNA, proteins, and enzymes are much larger than the typical size of microporous channels which lead to mesocavities in mesoporous MOFs. For adsorption of biologically active organic compounds, MOFs with extralarge pore sizes are needed. The adsorption of indomethacin on several MIL-101 MOFs was studied from the solution in tetrahydrofuran (THF). The interactions of the molecules of adsorbed indomethacin and the molecules of coadsorbed THF solvent with the metal sites and the linkers in the MOFs were investigated by solid-state nuclear magnetic resonance (NMR) spectroscopy. Adsorption of several active pharmaceutical ingredients (APIs) was studied on commercial mesoporous MOF Basolite F300, which is similar to MIL-100(Fe).
