ABSTRACT

Adenovirus (Ad)-based vectors are one of the most commonly used gene delivery vehicles in molecular biology and gene therapy applications. For over 60 years, researchers have studied the basic biology of Ad, unraveling the subtle, yet profound, interactions between the virus and the host. With our increased understanding of the biology of the virus, we have refined the function of Ad as a gene delivery tool, and tailored it to disease-specific applications. For example, removal of all viral genes

Abstract ......................................................................................................................1 1.1 Introduction ......................................................................................................2 1.2 Ad Biology ........................................................................................................2