ABSTRACT
There are important factors in animal production, breeding, and experiments, which include genetic background, microorganisms, nutrition, living environment, and facilities for laboratory animals. This chapter focuses on how to manage these factors in order to standardize laboratory animals and animal experiments. The genetic background of laboratory animals is one of the main factors that influences the variation of experimental results. Infected laboratory animals are an important source of microbiological contamination. Although great efforts are made for microbiological quality control, the animals brought from outside can possibly bring pathogenic microorganisms into a new facility. Microbiological quality control is divided into control over the barrier system and laboratory animals. The quality of laboratory animals and experimentations are mainly based on a full understanding of the different microorganical status of the animal stocks.
