ABSTRACT
This chapter highlights the significance of multicomponent reactions (MCRs) for the development of the piperidine skeleton. Piperidine is a highly important heterocycle in organic chemistry and present in many natural alkaloids. Piperidine synthesis via multicomponent fashion continues to be a very active field and will continue to be an important endeavor in the future. The chapter provides a guideline for researchers to develop new and creative multicomponent routes to the piperidine heterocyclic frame. It describes a one-pot, multicomponent reaction by using tetrabutylammonium tribromide (TBATB) as a catalyst for the synthesis of highly functionalized piperidine derivatives. The chapter discusses a one-pot, three-component transformation between aromatic aldehydes, amines, and acetoacetic esters in ethanol at reflux conditions for the synthesis of functionalized piperidine scaffolds based on an aqua-compatible ZrOCl2.8H2O catalyst. A wet picric acid catalyzed reaction has been developed by the Mukhopadhyay group for the synthesis of syn-diastereoisomer in the diastereoselective synthesis of highly functionalized piperidine derivatives.
