ABSTRACT
This chapter focuses on the representative literature of one-pot total synthesis and highlights the process that relates to multicomponent domino reactions (MDRs). It presents the mono-or bimolecular reaction, which successfully culminated in one-pot total synthesis to reveal the entire landscape of this research field. The chapter discusses the one-pot, multistage total synthesis, microwave-assisted one-pot total synthesis, and direct one-pot total synthesis. It describes the biomimetic synthesis of grossularines-1 with a one-pot, multistage strategy. The chapter provides the synthesis of Pyrrolo[2,1-b]quinazoline alkaloids belong to a special family of quinazolinone alkaloids. The one-pot total synthesis of ß-carboline alkaloids with a pyrido[3,4-b]indoles core structure have a broad range of biological activities, including antimicrobial, antifungal, antitumor, cytotoxic, and antiplasmodial properties. Based on a logical retrosynthetic analysis, employing aryl ethyl ketone, tryptamine derivatives, and stoichiometric molecular iodine, eight ß-carboline alkaloids, including the eudistomins Y1-Y6 family, papaveraldine, and pityiacitrin, can be formed directly through a one-pot protocol.
