chapter  6
16 Pages

Adhesion of Polymeric Films

Adhesion between a polymer and the surface of a solid is a major prerequisite for the lm coating of pharmaceutical dosage forms [1-3]. Loss of adhesion may lead to an accumulation of moisture at the lm-tablet interface, potentially affecting the stability of drugs susceptible to hydrolytic degradation [4]. Poor adhesion may also compromise the mechanical protection that the coating provides to the substrate [5]. In addition, experiments on adhesion are useful to the pharmaceutical scientist during formulation development to investigate the relationship between tablet excipients and polymeric lm-coating formulations [6].