ABSTRACT
Cancer metastasis, the spread of cancer cells from a primary tumor site to a secondary organ, accounts for 90% of deaths among cancer patients [1]. In order for cancer cells to transmigrate and colonize a distal organ, however, they must overcome several barriers in a series of steps termed the “metastatic cascade.” In the first step, tumor cells of epithelial origin at the primary site undergo an epithelial-to-mesenchymal
14.1 Cancer Metastatic Cascade ...........................................................................287 14.2 Microfluidic Technologies to Study the Metastatic Cascade ........................288 14.3 Microfluidic Technologies to Study Cancer Cell Migration .........................290
