ABSTRACT
Optical coherence tomography (OCT) is a noninvasive medical imaging technique with micrometer resolution, millimeter penetration, and three dimensional information. This chapter introduces Doppler-based OCT methods, including phase-resolved color Doppler, phase-resolved Doppler variance, and intensity-based Doppler variance. It reviews the applications, improvement, and multimodality imaging of Doppler OCT in the investigation of cerebral blood flow. Since the first 2D in vivo Doppler OCT imaging was reported in 1997, Doppler OCT has developed rapidly. It has become a significant method for the mapping and measurement of cerebral blood flow. A general structure of an OCT system based on a Michelson interferometer including a low coherence broadband light source, a reference light path, a sample light path, a coupler, and a photo detector. A common Fourier domain OCT system can be classified into swept-source OCT and spectral-domain OCT according to the types of the light source.
