ABSTRACT

There is a renewed interest in the fundamentals of energy metabolism, yet most people base their understanding on the views of generalists expressed in elementary textbooks. New techniques that enable analysis of thousands of metabolites provide useful data, but do not themselves substitute for an understanding of the fundamentals of metabolism. While classical ideas of metabolism are also valuable, some earlier ideas have not withstood further investigation. This book presents a personal philosophy but rests on what is broadly accepted by metabolic biochemists over the past few decades.

chapter 1|10 pages

Metabolic Perspective

chapter 2|22 pages

Glycolysis

The Reference Pathway

chapter 3|34 pages

Mitochondria and Energy Production

chapter 4|24 pages

Principles of Pathway Connectivity

chapter 5|30 pages

Enzymes and Their Inhibition

chapter 6|60 pages

Tissue-Specific Pathways

chapter 7|40 pages

Cellular Signaling Systems

chapter 8|12 pages

Pathways and Energy Contributions

chapter 9|8 pages

Computer Modeling Studies in Metabolism

chapter 10|14 pages

Medical Issues Related to Metabolism