ABSTRACT
Learning objectives ■ The neuromuscular junction ■ Structure and function of the neuromuscular junction ■ Functional structure of the nicotinic ACh receptor at the NMJ ■ Drugs that modify neuromuscular transmission ■ Neuromuscular
blocking drugs ■ Non-depolarising neuromuscular blocking drugs ■ Depolarising neuromuscular blocking drugs ■ Anticholinesterases
Learning objectives Be able to sketch a diagram of the NMJ, showing the key components. ■ Know the key events as given here from arrival of the impulse at the ■ terminal to the muscle contraction. Be ready to give examples of non-depolarising and depolarising ■ neuromuscular drugs together with examples. Be able to explain the main distinction between the terms ‘competitive’ ■ and ‘non-competitive’ neuromuscular block. Know some of the main precautions and adverse effects of neuromuscular ■ blocking drugs. Be able give examples of the various anticholinesterases and to explain ■ briefl y how they work. Know what anticholinesterases are used for. ■ Be able to give examples of irreversible anticholinesterases, the antidote ■ and be aware of the implications of irreversible anticholinesterase action.
