ABSTRACT
Learning objectives Be familiar with the different eiconasoids covered here and their receptors. ■ Study the fl ow diagram for biosynthesis of the eiconasoids. ■ Know that NSAIDs, including aspirin, work by inhibiting the COX-2 ■ enzyme. Be aware of the protective effect of prostacyclin by inhibiting platelet ■ aggregation. Know that thromboxane promotes platelet aggregation. ■ Be acquainted with the names of drugs that block interleukin action. ■
LTA4: Converted to LTB4 ❚ LTB4: Chemotactic ❚ * infl uence on migrating neutrophils LTC4 ❚ LTD4 ❚ LTE4 ❚ LTF4 ❚
Prostanoids, (for example): ■ prostaglandins, (for example): ❚
PgD ♦ 2: evidence for involvement in rapid eye movement sleep, muscle contraction and relaxation, CNS trophic factor and neuromodulator; bronchoconstriction and airways remodelling PgE ♦ 2: involved in uterine function, especially in implantation and parturition; contributes to tissue oedema, pain, and cytokine production in infl amed tissues; maintenance of gastric mucosal integrity; maintenance of glomerular fi ltration and renal blood fl ow
Cystinyl leukotrienes: mediators of bronchoconstriction, increased capillary permeability and fast hypersensitivity responses
PgF2 ♦ α: mediates pain and infl ammation (see aspirin, p. 164); protects against coagulation in endothelial tissue; involved in mammalian reproduction.
