ABSTRACT
What would happen if we could arrange the atoms one by one the way we want them? —Richard Feynman, Physicist (1959)
All experimental biophysical techniques clearly involve measurement and application of forces in some form or another. However, there is a subset of methods that are designed specifically to either measure the forces generated in biological systems, or to control and manipulate them. Similarly, there are tools that do not characterize biological forces directly, but which primarily utilize force methods in their mode of operation, for example, in using pressure gradients to purify biomolecular components.
