The flood metaphor describes the situation the science and technology practitioners of Eastern Europe now find themselves in. The economic, political, institutional, and cultural foundations upon which their working environment was predicated have been all but swept away. Especially for the East Europeans, who unlike their Soviet colleagues cannot entertain any illusions about their countries' R&D systems being sustainable as more or less independent entities, the next years will mean a startling period of transition. The transition will be one not only of domestic institutions but of fundamental orientation as well. East European science and technology1 needs to rejoin the global mainstream to survive and to be effective. This paper discusses the means for doing so and the problems to be faced.