This chapter discusses computer-based cognitive retraining (CBCR), non-invasive brain stimulation (NIBS), and virtual reality training (VRT). In the last ten years CBCR has become extremely popular, not only in a clinical context but also for people in the general population wanting to improve cognitive functioning. For CBCR to be applied as a method for cognitive rehabilitation in patients with ABI it is also important to know what individual factors could influence the success of the intervention in this population. While there is overall support for the effectiveness of CBCR in other populations, such as children with attention deficit hyperactivity disorder (ADHD) or learning disabilities. The evidence on novel forms of cognitive rehabilitation is growing. Overall there was consistent evidence that CBCR can be effective in improving memory function on trained tasks, and tasks related to the trained tasks, in individuals with acquired brain injury (ABI), but only a few studies found a generalised effect to non-trained tasks.