ABSTRACT
In this chapter the effect of pathology on fatigue will be discussed using two prime examples: multiple sclerosis (MS) and myasthenia gravis (MG). These diseases are particularly relevant as patients report significant fatigue and difficulty carrying out activities of daily living. However, one interesting aspect that will be highlighted is that the nature of fatigue in MS is centrally mediated, whereas in MG it is peripherally mediated. The reasons for this apparent difference will be highlighted as they pertain to the development of fatigue during physical exertion. A further aspect of both pathologies is the apparent heat sensitivity that these patients report and how this symptom relates to increased feelings of fatigue and reduced physical capacity.
