George Bernard Shaw once said that reasonable people adapt themselves to the world but unreasonable people adapt the world to themselves. Thus all progress must depend on unreasonable people. In a sense, this book explores how these ‘unreasonable people’ may interact to remould and refashion the world around them through the lens of institutional change. In this opening chapter, I consider evolving discussions on ‘institutions’, towards investigating in-depth institutional processes in women’s enterprise in the context of Afghanistan. I present the overall framework for the study, emphasising the epistemological departure, and guiding research themes. I reflect on the methodological techniques and fieldwork in the fragile and war-stricken Afghan setting. Introducing the research cases, I finally give a brief overview of the specific businesses featured in this book, describing their background, situation and reasons for selection. Looking ahead, I discuss the emerging book structure and arguments.