This chapter helps readers to determine the appropriate content for the Methods section, organize the information presented in the Methods section, and write the Methods section in appropriate scientific style and edit style problems that commonly arise in the Methods section. The content of the Methods section describes the experimental procedures used in the current research manuscript. Peer reviewers and journal editors report that the Methods section is usually the most flawed section of manuscripts submitted for publication, and it is often the section responsible for a manuscript's outright rejection. Novice writers often create Methods sections that are far too detailed for some steps highly important details. The content of the Methods section is not necessarily presented chronologically in regard to when the procedures were actually conducted but rather is organized and presented to establish a rational narrative in which the outcome from one experimental subsection leads logically to the next.