Within the context of Immanuel Kant's Critical philosophy, are spatiotemporal causal relations. Affection is one relational element within this ordered set of spatiotemporal causal relations, whose specific function it is to reveal structural features of the affecting object to the receptive subject. All causal relations must be spatiotemporal, however, insofar as causal relations can only be obtain within space and time. Affection through the thing-in-itself is uncognizable in principle since the process takes place in the noumenal realm; affection through appearances remains mind-dependent since the spatiotemporal phenomenal world is merely a representation of the noumenal self. The thing-in-itself affects the subject and so must serve as one of the relata in the affection relation. Kant obliquely characterizes affection in terms of a causal-dynamic relation in the Amphiboly; he explicitly characterizes affection in terms of a causal-mechanical relation in Metaphysical Foundations of Natural Science (MFNS).