This chapter examines the experience of living with HIV disease, focusing on the multiple problems experienced by individuals living with HIV. I utilize client-level data collected between 2002 and 2007 by the Regional HIV/ AIDS Consortium (serving a 13-county area and headquartered in Charlotte, North Carolina). The project was funded by the Substance Abuse and Mental Health Services Administration (SAMSHA) and was one of over 250 targeted capacity grants for enhanced substance abuse services. I served as the evaluator on the project. Each year, a maximum of 68 clients were referred to enhanced substance abuse services (referrals were generally made by case managers), and each client was interviewed at in-take, 6 months, and 12 months by staff at the Regional HIV/AIDS Consortium. The same individual interviewed the clients for all three interviews and worked to get the client into substance abuse treatment, hence playing the role of a clinician researcher. The instrument used was developed by SAMHSA, and was enhanced by me to collect additional data on social support and treatment adherence. While the data was entered in a governmental data tracking system, I also entered the data into my own software program for analysis. Over the course of the 5-year grant, intake data was collected on 320 clients, 6-month follow up data on 229 clients, and 12-month follow up data on 176 clients.