ABSTRACT
This chapter examines the ethical and regulatory issues arising from the draft Regulation, including the regulatory approach to the mitochondrial donor who would enable these techniques. The power to put this regulation forward to Parliament was inserted into the amending Human Fertilisation and Embryology (HFE) Act 2008. The therapeutic use for maternal spindle transfer (MST) and pronuclear transfer (PNT) that seems likely to be commercially successful in non-UK regulatory systems, that resolves fertility problems arising from inadequate mitochondrial function linked to intending mothers age. A very commonly cited objection to the use of both PNT and MST has been that mitochondrial donation would mean children being born with three parents, or two mothers. PNT requires two eggs to be fertilised and puts each resulting embryo to different uses, each creating different genetic connections between the sperm donor and the resulting child. The mitochondrial donor should apply to a sperm donor solely creating an embryo for zygotic enucleation in the PNT process.
