ABSTRACT

In this chapter, the author reviews work from his laboratory that helps decipher the molecular cascade leading to the synaptic reorganization that appears to form the neural representation of a simple form of memory. He tries to place our results in the more holistic context of time- and space-dependent brain systems subserving memory. There is an interesting way in which thinking about the physiological and cellular mechanics of learning and memory formation has become divorced from knowledge about the processes of remembering and of memory systems derived from neuropsychology. To be compatible with the phenomenology of memory, cellular and physiological models should make some effort to accommodate to the neuropsychological evidence. Most memory modeling at the neurophysiological level has focused on associative learning. Learning to suppress pecking at the bitter bead initiates an intracellular cascade of cellular processes that occurs in identified regions of the chick forebrain