ABSTRACT
Animal models are used frequently in biomedical research to discover underlying mechanisms responsible for disease and to develop an understanding of basic biological processes. In that regard, our laboratory has initiated a program of research concerning the development of appropriate animal models for the study of possible mechanisms of neurotoxicity of selected chemicals. An example of this endeavor is our recent work (Gerhart, Hong, & Tilson, 1983; Gerhart, Hong, Uphouse, & Tilson, 1982; Hong, Tilson, Uphouse, Gerhart, & Wilson, 1983) with chlordecone (KeponeR), a chlorinated hydrocarbon insecticide similar in effect to DDT.
