ABSTRACT
In 1937 , Papez (1937) proposed a neuroanatomical central nervous system (CNS) mechanism for emotions, elaborated as early as 1949 by MacLean (1949, 1952), who not only continued the basic animal work, but who also proposed important analogies between animal and human emotions and behavior. In 1973, Eichelman and Thoa (1973) described applications of modern techniques of neurochemical assessment to models of aggression in animals. Though a number of neurochemical systems have been implicated in the aggressive behavior of animals, the most consistent findings have involved neurotransmitters. Though not exclusively, changes in the CNS indoleamine, viz. serotonin (SHT), and catecholamines, viz. norepinephrine (NE) and dopamine (DA), neurotransmitter systems, which largely function in inhibitory and excitatory roles, respectively, have been most associated with reproducible findings.
